时间限制的养揭示了神经呼吸钟在优化小鼠每日呼吸器-代谢合中的作用
Aaron A Jones1, Gabriella M Marino1, Deanna M Arble1
1Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, United States.
概括
每天的呼吸节奏是由新陈代谢速率的变化和呼吸细胞内的内在神经钟调节的. 这些发现表明,仅仅是新陈代谢率不足以驱动通风模式,突显了细胞昼夜计时的作用.
科学领域:
- 生理学 生理学 生理学
- 时间生物学 时间生物学
- 神经科学是一个神经科学.
背景情况:
- 上神核 (SCN) 主钟调节了通风 (V̇e) 的日常节奏.
- 驱动每日V·e节律的精确机制,无论是SCN驱动的代谢率还是其他生理节律因素的次要因素,仍然不清楚.
研究的目的:
- 为了研究新陈代谢率对每日维生素节律的影响.
- 确定呼吸神经元中细胞昼夜钟在编排维节律中的作用.
主要方法:
- 时间限制的食被用来实验性地改变小鼠的代谢率.
- 监测了通风 (V·e),氧气消耗 (V·o2) 和二氧化碳产量 (V·co2).
- 在野生型和缺乏BMAL1的小鼠 (BKOP) 中分析了Ve节律,这些小鼠缺乏Phox2b表达呼吸细胞中的分子钟.
主要成果:
- 改变食时间改变了新陈代谢和呼吸节律之间的同步,表明单独的新陈代谢率是不够的.
- 在呼吸细胞 (BKOP) 中缺乏BMAL1的小鼠在白天食时表现出不受限制的V·e节奏,与V·co2节奏保持一致.
- 与野生类型的小鼠相比,BKOP小鼠在活跃 (夜间) 阶段食时,V·e或代谢节律没有差异.
结论:
- 每日维节节律受到SCN调节的新陈代谢率和呼吸神经元内的内在昼夜钟的影响.
- 在Phox2b表达细胞中的神经昼夜钟在优化呼吸控制方面发挥着重要作用.
- 这些发现阐明了新陈代谢和神经昼夜机制在调节呼吸模式中的复杂相互作用.
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