Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Autoimmune Disorders01:29

Autoimmune Disorders

417
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
417
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

126
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
126
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

130
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
130
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.4K
Tumor Immunotherapy01:27

Tumor Immunotherapy

514
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
514
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

84
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
84

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Treatment of pruritus in primary sclerosing cholangitis: Analysis of the consortium for autoimmune liver disease registry.

Hepatology communications·2025
Same author

Candidates for liver transplant evaluated at satellite clinics at a large academic transplant center are less likely to be waitlisted.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2024
Same author

The Survival Benefit of Reabstinence After Harmful Alcohol Use Following Early Liver Transplant for Severe Alcohol-Associated Hepatitis: A Multicenter ACCELERATE Study.

The American journal of gastroenterology·2024
Same author

Safety and efficacy of continuous terlipressin infusion in HRS-AKI in a transplant population.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2024
Same author

The delta in management of HDV/HBV coinfection: Lessons from a case.

Clinical liver disease·2024
Same author

Could the answer to NAFLD be hidden in diabetic therapy? The impact of T2DM treatment on NAFLD.

Clinical liver disease·2024

相关实验视频

Updated: Jun 24, 2025

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.2K

自身免疫性肝炎:当前和未来的治疗方法

Nancy S Reau1, Craig S Lammert2, Ethan M Weinberg3

  • 1Section of Hepatology, Hepatology Services, Rush University Medical Center, Chicago, Illinois, USA.

Hepatology communications
|June 5, 2024
PubMed
概括

自身免疫性肝炎 (AIH) 是一种复杂的肝病,影响了许多人,目前的治疗方法会引起副作用. 新的,个性化的,无类固醇的方法对于更好的结果和降低风险至关重要.

更多相关视频

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
00:06

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

8.8K
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

6.8K

相关实验视频

Last Updated: Jun 24, 2025

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.2K
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
00:06

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

8.8K
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

6.8K

科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 免疫学 免疫学 免疫学
  • 自免疫性疾病 自免疫性疾病

背景情况:

  • 自身免疫性肝炎 (AIH) 是一种慢性,异质性肝病,主要影响女性,可能导致肝硬化和肝衰竭.
  • 目前的标准治疗包括免疫抑制剂,但长期使用会产生显著的不良影响.
  • 复杂的AIH病变包括免疫细胞透和炎症级联,但向治疗仍然有限.

研究的目的:

  • 突出推进AIH治疗范式的挑战.
  • 强调需要改进临床试验设计和结果评估.
  • 倡导个性化和无类固醇的治疗策略.

主要方法:

  • 审查目前对AIH病原和治疗局限性的理解.
  • 对临床试验进行障碍的分析,包括患者招募和多样性.
  • 讨论对定义结果和适应性研究设计的需求.

主要成果:

  • 治疗AIH的进展落后于其他自身免疫性疾病.
  • 临床试验面临重大障碍,包括患者多样性和结果测量.
  • 目前的治疗策略缺乏个性化,并导致类固醇相关的副作用.

结论:

  • 个性化和无类固醇治疗方法对于改善AIH预后至关重要.
  • 解决临床试验中的挑战对于开发新疗法至关重要.
  • 尽量减少类固醇相关的不良影响是提高患者生活质量的关键目标.