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肺炎球菌携带和血清型分布在患有性综合征的儿童中
Tugba Erem1, Asli Kavaz Tufan2, Omer Kilic3
1Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, TR-26040, Turkey.
Pediatric nephrology (Berlin, Germany)
|June 5, 2024
概括
患有性综合征 (NS) 的儿童表现出与健康儿童相似的肺炎球菌携带率. 然而,监测NS患者的血清型分布对于评估新型肺炎球菌疫苗对侵入性肺炎球菌疾病 (IPD) 的有效性至关重要.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 患有性综合征 (NS) 的患者面临侵入性肺炎球菌病 (IPD) 的风险增加.
- 肺炎球菌载体研究对于识别传染性血清型和告知免疫策略至关重要.
- 关于NS儿童肺炎球菌携带频率的数据有限.
研究的目的:
- 评估患有NS的儿童肺炎球菌携带率.
- 确定患有NS的儿童肺炎球菌分离物的血清型分布.
- 为了比较NS儿童和健康对照儿童之间的携带率和血清型.
主要方法:
- 实时PCR测定用于检测鼻口腔拭片样本中的肺炎球菌载体.
- 从98名患有NS的儿童和100名健康对照儿童收集了样本.
- 分离物被用实时PCR测定血清型.
主要成果:
- 在患有NS的儿童中,肺炎球菌携带率为44.9%.
- 在NS队列中,肺炎球菌疫苗的接种率很低.
- 在NS和健康对照儿童之间,没有观察到总体,PCV13或非PCV13血清型携带率的显著差异.
结论:
- 肺炎球菌携带率在患有NS的儿童和健康对照人群之间是可比的.
- 在NS患者中血清型分布突显了新型肺炎球菌疫苗在IPD预防方面的重要性.
- 定期监测IPD和血清流行病学对于评估NS儿童疫苗的有效性至关重要.
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