在复发性急性中耳炎中肠道微生物群的组成:一个横截面的观察性研究
Andrej Florjan1, Maja Rupnik2,3, Aleksander Mahnic4,5
1Department of Otorhinolaryngology and Cervicofacial Surgery, General Hospital Celje, Oblakova ulica 5, 3000, Celje, Slovenia.
Folia microbiologica
|June 5, 2024
概括
在儿童中,复发性急性中耳炎 (rAOM) 显示出有限的肠道微生物群差异. 然而,像Turicibacter这样的特定细菌与感染频率相关,这表明潜在的肠耳连接需要更多的研究.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
背景情况:
- 复发性急性中耳炎 (rAOM) 是一种常见的儿童疾病,通常对治疗有抗性.
- 研究主要检查rAOM中的鼻微生物组变化,忽视了肠道微生物组的作用.
研究的目的:
- 调查肠道微生物组组成和1-6岁儿童的rAOM之间的关联.
- 识别肠道中与rAOM或感染频率相关的特定细菌种群.
主要方法:
- 35名儿童的横截面观察前性研究 (16名RAOM,19名对照).
- 便和鼻样本是在无抗生素期后采集的.
- 16S rRNA基因扩增序列测序 (V3-V4区域) 用于分析微生物群组成.
- 调查问卷数据收集了诸如托儿所出勤等混因素.
主要成果:
- 在rAOM和对照组之间,整体肠道微生物群组成的显著差异有限.
- 六种细菌种群在差异表示中显示出微弱的统计学意义.
- 图里西巴克特与连续多次感染的相关性最为显著.
- 托儿所的出席是肠道微生物群的显著改变者,独立于rAOM.
结论:
- 肠道微生物组在患有rAOM的儿童中显示出有限的直接组成差异.
- 特定肠道细菌 (如Turicibacter) 与感染频率之间的相关性表明存在潜在的间接联系.
- 需要进一步的研究来阐明肠道微生物组在rAOM病变发生中的作用.
相关概念视频
01:23Anatomy of the Intestines
71.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.8K
01:30Tonsillitis I: Introduction
234
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
234