相关实验视频
Updated: Jun 24, 2025

08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
15.7K
多种选择:如何选择前线转移性黑色素瘤的治疗方法
Lucy Boyce Kennedy1, April K S Salama2
1Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Taussig Cancer Institute, Cleveland, OH, 44195, USA.
Current oncology reports
|June 5, 2024
概括
对于晚期黑色素瘤,PD-1 抑制剂是大多数患者的首线治疗. 组合免疫疗法提供了更好的结果,但增加了毒性,目前正在研究最佳治疗选择.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 皮肤病学 皮肤病学
背景情况:
- 先进的黑色素瘤治疗景观正在迅速发展,新的向和免疫疗法.
- 为转移性黑色素瘤选择最佳的前线治疗是临床上的挑战,因为有许多选择.
研究的目的:
- 审查目前对转移性黑色素瘤的前线治疗选择.
- 为选择合适的治疗方案提供实际指导.
主要方法:
- 审查最近报告的随机临床试验数据.
- 分析不同治疗策略的疗效和毒性概况.
主要成果:
- 建议使用PD-1检查点抑制剂作为不可切除黑色素瘤的前线治疗,无论BRAF突变状态如何.
- 与单个药物相比,组合免疫疗法显示出更好的结果,但毒性增加.
- 目前还没有经过验证的生物标志物来指导个性化治疗选择.
结论:
- 前线PD-1抑制剂治疗是晚期黑色素瘤的标准治疗方法.
- 组合免疫疗法策略是有希望的,但需要谨慎的毒性管理.
- 需要进一步的研究来确定生物标志物以进行个性化治疗选择,并优化疗效,同时最大限度地降低晚期黑色素瘤的毒性.
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Tumor Immunotherapy
514
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
514

