瑞典扩大收养研究对不良应激反应和创伤后应激障碍的研究
Ananda B Amstadter1,2, Linda Abrahamsson3, Shannon Cusack1,2
1Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond.
JAMA psychiatry
|June 5, 2024
概括
负面应激反应 (ASR) 和创伤后应激障碍 (PTSD) 通过遗传和环境养育因素显示跨代传播. 共同的创伤事件部分解释了环境对ASR和PTSD的影响.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 众所周知,创伤后应激障碍 (PTSD) 和不良应激反应 (ASR) 在一代内受到遗传和环境因素的影响.
- 之前的双胞胎研究表明遗传和环境影响的复杂相互作用,但没有研究利用采用设计来调查跨代传播.
研究的目的:
- 为了调查ASR和PTSD从父母传给后代的跨代传播.
- 为了区分遗传与环境养殖因素在这种传播中的相对贡献.
主要方法:
- 一项大规模的瑞典队列研究分析了来自6种家庭类型 (包括收养家庭) 的2,194,171对父母-子女的全国性注册数据.
- 对ASR/PTSD的亲子相似性使用四相对关系进行了评估.
- 进行了敏感性分析,以控制潜在的共享创伤事件.
主要成果:
- 对遗传和养殖因素都观察到显著的跨代相关性.
- 在控制共享创伤时,仅养育相似性的相关性下降,这表明环境因素发挥了作用.
- 保守的敏感性分析表明,养殖相关性与遗传相关性相当.
结论:
- ASR和PTSD表现出跨代传播,受遗传和养殖环境的影响.
- 共同的创伤经历部分介于观察到的环境传播.
- 这些发现突显了跨世代的压力相关疾病的复杂病因.
相关概念视频
Introduction to Stress and Lifestyle
102
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
102
Post-traumatic Stress Disorder
31
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
31
Psychological Responses to Stress
53
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
53


