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来自白花的外体样纳米:特征,吸收稳定性和对电离辐射的保护

Yunying Ling^1,2, Xue Li^1,2, Hang Gao^1,2

¹School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.

Food & function

|June 5, 2024

概括

毕阳花衍生出的外体样纳米微粒 (BFMELNs) 显示出作为天然辐射保护剂的前景. 这些纳米纤维通过恢复血液指数和减轻器官损伤来保护辐射诱导的氧化应激.

科学领域:

纳米医学是一种纳米医学.
自然产品自然产品
辐射保护剂辐射保护剂

背景情况:

饮食衍生出的外体样纳米纤维模仿哺乳动物外体.
白阳花具有已知的辐射保护性质.

研究的目的:

调查比扬花衍生的外体样纳米纤维 (BFMELNs) 的辐射保护作用.
为了探索来自比扬花的新型活性物质.

主要方法:

关于BFMELN的大小,稳定性和电荷的特征.
细胞吸收机制的评估 (克拉和迪尼因介导的细胞分裂).
在小鼠体内抗氧化和辐射保护作用以及体内疗效的评估.

主要成果:

BFMELN表现出理想的大小,负表面电荷和稳定性.
通过HL-7702和Caco-2细胞观察到有效的细胞吸收.
BFMELNs在体外表现出显著的抗氧化和辐射保护作用,并在体内恢复血液指数和减轻器官损伤的有效性.

结论:

BFMELNs是稳定的,具有抗氧化和辐射保护性质的生物相容纳米纤维.
作为天然纳米剂,BFMELN显示出防止辐射诱导的氧化应激损伤的潜力.

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