骨肌肉代谢功能障碍与在食食品添加剂中循环的氧甲基氨酸引起的漏肠
Hinako Kodani1, Wataru Aoi1, Mikiko Hirata1
1Laboratory of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.
概括
由于饮食中的二氧化 (TiO2) 引起的漏肠,会损害全身葡萄糖代谢和骨肌肉功能. 溶解纤维改善了肠道屏障功能和代谢健康,这表明肠道健康和整体代谢调节之间存在联系.
科学领域:
- 代谢健康 代谢健康
- 胃肠病学 胃肠病学
- 肌肉生理学 肌肉生理学
背景情况:
- 肠道透性受损 (漏肠) 会导致系统性炎症和代谢功能障碍.
- 漏肠对骨肌肉新陈代谢的影响,这是营养消耗的关键部位,尚不清楚.
研究的目的:
- 为了研究饮食引起的肠壁功能障碍对小鼠全身和骨肌肉葡萄糖代谢的影响.
- 探索碳甲氨酸 (CML) 在调解这些代谢障碍中的作用.
主要方法:
- 给小鼠食含有二氧化 (TiO2) 的饮食,以诱导肠道屏障功能障碍.
- 评估了肠道透性,全身葡萄糖和胰岛素耐受性,骨肌肉葡萄糖吸收,胰岛素信号和炎症标志物.
- 研究了CML对培养的肌肉管的影响.
- 评估了可溶性食纤维补充剂的影响.
主要成果:
- 用TiO2养的小鼠表现出肠道透性增加,葡萄糖/胰岛素耐受性受损,骨肌肉葡萄糖吸收减少.
- 在食TiO2的小鼠中观察到高水平的促炎因素和碳氧甲基氨酸 (CML) 水平.
- 慢性肌痛性淋巴瘤治疗减少了神经管中依赖胰岛素的葡萄糖吸收.
- 可溶性食纤维补充剂改善了葡萄糖不耐受,减少了CML,并改善了肠道屏障功能.
结论:
- 饮食引起的肠壁功能障碍导致全身葡萄糖不耐受和骨肌肉代谢功能障碍,部分由循环CML介导.
- 肠道健康在调节全身和肌肉代谢健康方面发挥着至关重要的作用.
- 溶性食纤维通过改善肠道屏障功能和降低CML水平来减轻这些负面影响的潜力.
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