3D打印的个性化的多孔骨部件,用于重建初级关节整形手术中广泛的骨缺陷
Zhuangzhuang Li1,2, Yi Luo1,2, Minxun Lu1,2
1Department of Orthopedics and Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Orthopaedic surgery
|June 5, 2024
概括
定制的3D打印的骨部件为在全关节整形术 (THA) 中广泛的骨缺陷提供了可行的解决方案. 这些植入物证明了精确的重建和稳定的支持,改善了患者的部功能.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料工程 生物材料工程
- 医疗成像医学成像
背景情况:
- 在关节整形术 (THA) 中管理广泛的关节骨缺陷存在重大挑战.
- 传统方法可能无法充分解决严重的骨损失,影响长期结果.
研究的目的:
- 评估使用3D打印的个性化多孔骨元件的可行性和初步结果.
- 评估这些定制植入物在重建初级THA期间的acetabular缺陷中的有效性.
主要方法:
- 一项对7名患者进行的回顾性研究,这些患者接受了3D打印的acetabular组件的初级THA治疗.
- 使用帕普洛斯基分类 (IIIA和IIIB) 进行形骨缺陷的术前评估.
- 定制植入物设计和手术植入,随后使用哈里斯部分数 (HHS) 进行功能和放射性结果评估.
主要成果:
- 平均随访40个月,没有随访损失.
- 在HHS从44到88显著改善.
- 观察到精确的组件配合,最小的旋转中心差异 (2.3mm水平,2.1mm垂直),以及密切的骨植入物接触.
- 没有观察到松,脱或突起等并发症.
结论:
- 3D打印的个性化骨元件提供了准确的重建和稳定的机械支.
- 这些定制植入物在THA.中对广泛的骨缺陷表现出有利的短期功能结果.
- 这种方法代表了复杂的acetabular重建的有希望的替代方案.
相关概念视频
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...