牙周炎和炎症性肠病之间的双向关联:对纵向研究进行系统审查,并进行元分析和试验顺序分析
Qiuhao Wang1, Shuze Chen1, Jieyu Zhou1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Journal of periodontal research
|June 5, 2024
概括
牙周炎不会增加整体炎症性肠病 (IBD) 的风险,但会增加性结肠炎 (UC) 的风险. 相反,IBD患者面临患有牙周炎的风险更高,突出显著的双向联系.
科学领域:
- 口腔健康和胃肠道学
- 系统性审查和元分析
- 流行病学 流行病学
背景情况:
- 牙周炎和炎症性肠病 (IBD) 之间的关系需要关于时间方向性的澄清.
- 现有的证据不足以确定确定的因果关系或理解双向关联.
研究的目的:
- 系统地审查和元分析评估牙周炎和IBD之间的双向关联的纵向研究.
- 评估牙周炎是否是IBD的风险因素,反之亦然,包括IBD亚型.
主要方法:
- 在五个主要数据库 (PubMed,Embase,Web of Science,Scopus,Cochrane Library) 进行系统搜索,截至2024年2月27日.
- 包括纵向研究 (队列,嵌套病例对照) 与聚合风险比率 (RR) 和危险比率 (HR) 的元分析.
- 试验顺序分析 (TSA) 用于确认发现的可靠性.
主要成果:
- 牙周炎并没有显著增加IBD的总体风险 (RR=1.04).
- 牙周炎与性结肠炎 (UC) 的风险增加有关 (RR=1.12),但克罗恩病 (CD) 的风险没有增加 (RR=0.98).
- 患有IBD的患者患有牙周炎的风险显著增加 (HR=1.37).
结论:
- 牙周炎不是IBD的整体风险因素,但增加了UC风险.
- 随着时间的推移,IBD患者患牙周炎的风险更高.
- 需要进一步进行高质量的纵向研究,以阐明IBD亚型对牙周炎发病率的影响.
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