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免疫检查点抑制剂与单独的化疗在扩散性多间皮质瘤中的比较疗效

Xuemei Zhang¹, Lele Chang², Qian Ma²

¹Department of Radiation Oncology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, RD. Minjiang, Dist. Kecheng, Quzhou, Zhejiang, China.

Thoracic cancer

|June 5, 2024

概括

免疫检查点抑制剂 (ICI) 与化疗相比,显著改善了中国扩散性多发性骨髓瘤患者的生存率. 早期免疫疗法添加证明了无进展的优越性和整体生存益处.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
胸部瘤学胸部瘤学

背景情况:

扩散性多层层层瘤是一种罕见且具有攻击性的癌症.
从历史上看,治疗选择是有限的,化疗是标准方法.
关于免疫检查点抑制剂 (ICI) 等较新的治疗方法的现实数据对于优化患者护理至关重要.

研究的目的:

为了比较免疫检查点抑制剂 (ICI) 与传统化疗的疗效和安全性.
评估ICI在中国患有扩散性多间皮质瘤的患者的实际结果.
为了确定治疗时间对生存效益的影响.

主要方法:

对90名在2019-2022年期间接受治疗的扩散性多叶半瘤患者的回顾性分析.
患者被分为ICI治疗组 (n=46) 和仅化学疗法治疗组 (n=44).
评估了无进展生存率 (PFS),总生存率 (OS),客观反应率 (ORR) 和疾病控制率 (DCR).

主要成果:

在ICI组中,PFS的中位数为10.0个月,而化疗的PFS为7.0个月,OS的中位数为24.7个月,而OS为15.8个月.
在ICI组中,客观反应率 (ORR) 较高 (52.2%对41.0%),疾病控制率 (DCR) (78.3%对70.0%).
卡普兰-梅尔分析证实ICI具有显著的PFS (HR:0.61) 和OS (HR:0.47) 益处,在治疗线上一致.

结论:

免疫检查点抑制剂 (ICI) 为非手术扩散性多叶层层瘤提供了比化疗更好的生存益处.
早期将免疫疗法纳入治疗方案可以改善治疗结果.
这些发现支持在这个患者群体的现实环境中使用ICI.

关键词:

化疗化疗是一种化学疗法.免疫疗法免疫疗法胸腔间皮瘤 (PLEURAL MESOTHELIOMA) 是一种多发性中皮瘤.在安全方面,安全是安全的.幸存率幸存率生存率

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