血 taurine 水平与 COVID 后病情的症状负担和临床结果有关
Mobin Khoramjoo1,2, Kaiming Wang2,3, Karthik Srinivasan4
1Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.
PloS one
|June 5, 2024
概括
低血 taurine 水平与后COVID 疾病 (PCC) 症状和不良事件有关. 在康复期间增加牛素可能会防止负面结果,这表明牛素是PCC的潜在治疗标.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID状况 (PCC) 影响10-20%的个人在SARS-CoV-2感染后,缺乏有效的治疗方法,并造成严重的健康和经济负担.
- 目前对PCC病理生理学和有效干预措施的理解仍然有限.
研究的目的:
- 调查PCC患者血 taurine水平和自我报告的症状之间的关联.
- 评估血 taurine 与PCC患者不良临床结果和炎症标志物的相关性.
主要方法:
- 在急性COVID-19和感染后六个月期间,与28名健康对照组相比,对117名患者的血蛋白质组和代谢组的分析.
- 使用多变量分析评估血 taurine 轨迹及其与临床事件的关联.
主要成果:
- 血 taurine 度与 PCC 症状有负相关性,与炎症,酸盐代谢和肠道失生症标志物相关.
- 在康复期间血 taurine 水平的增加与不良临床事件的减少相关,独立于并发症和急性 COVID-19 严重程度.
- 在急性和康复阶段之间增加的血 taurine 显示,针对预防不良事件的危险比率为 0.13 (p<0.001).
结论:
- 氨酸显示出作为PCC的预测生物标志物的潜力.
- 氨酸补充可能是缓解PCC的可行的治疗策略,需要进一步的大规模临床试验.
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