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Updated: Jun 24, 2025

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
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Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

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cAMP/PKA信号调节TDP-43的聚合和错位

Diana M Ho1, Muhammad Shaban2,3,4,5, Faisal Mahmood2,3,4,5

  • 1Department of Cell Biology, Harvard Medical School, Boston, MA 02115.

Proceedings of the National Academy of Sciences of the United States of America
|June 5, 2024
PubMed
概括

调节cAMP/PKA通路,通过准像Dunce和PKA-R2这样的基因,可以减少TDP-43蛋白聚合和错位化,改善肌缩侧面硬化症 (ALS) 模型中的运动缺陷.

关键词:
这就是ALS.在TDP-43中使用.cAMP/PKA 信号传输系统神经退行症的神经退行症蛋白质病变是一种蛋白质病变.

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