评估甲状腺自身免疫性妇女的卵巢储备
Adriana Leal Griz Notaro1,2, Filipe Tenório Lira Neto1,3, Giuliano Marchetti Bedoschi4
1Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brazil.
JBRA assisted reproduction
|June 5, 2024
概括
甲状腺自身免疫 (TAI) 可能会随着时间的推移微妙地影响卵巢储备. 患有抗thyroglobulin (anti-Tg) 抗体的女性表现出卵巢储量减少,特别是患有TAI的老年女性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 免疫学 免疫学 免疫学
- 妇女健康 妇女健康
背景情况:
- 甲状腺自身免疫 (TAI) 在生殖年龄的女性中很常见.
- 对于TAI对卵巢储备的影响尚未完全理解.
- 卵巢储备对于生育和成功的辅助生殖至关重要.
研究的目的:
- 为了比较有和没有TAI的女性之间的卵巢储备标记.
- 调查特异性抗体与卵巢储备之间的关联.
- 探索TAI妇女的卵巢储备与年龄相关的差异.
主要方法:
- 188名来自辅助生殖诊所的妇女 (18-47岁) 的回顾性分析.
- 使用抗米勒尔激素 (AMH) 和毛囊数 (AFC) 评估卵巢储备.
- 与TAI和没有TAI的女性之间的AMH和AFC的比较,根据年龄和抗体状况对子组进行分析.
主要成果:
- 在TAI和非TAI组之间没有AMH或AFC的总体差异.
- 在39岁以上的女性中,TAI的AMH趋势较低 (p=0.08).
- 具有抗甲状腺球蛋白 (抗Tg) 抗体的女性显著降低AFC (p=0.036) 和较高的患病率的抗Tg在低卵巢储备患者 (p=0.038).
结论:
- 在TAI的女性中,卵巢储备可能会逐渐受到损害.
- 抗铁血球蛋白抗体与卵巢储备的减少有关.
- 需要进一步的研究来阐明机制和临床影响.
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