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自组装的红外染料/米托克桑装载的Porphysomes纳米系统用于增强的组合化学-光热癌症治疗

Monika Pebam¹, Sajmina Khatun¹, Mohammad Sadik Ali¹

¹Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502284, India.

Colloids and surfaces. B, Biointerfaces

|June 5, 2024

概括

这项研究引入了用于化疗-光热疗法的新型体纳米颗粒,有效地破坏乳腺癌细胞,对健康组织的损伤最小. 这些纳米颗粒利用光激活进行向药物输送和癌细胞切除.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

化学光热疗法 (PTT) 为癌症治疗提供了一种有前途的非侵入性方法.
开发光响应纳米系统对于有针对性的药物输送和增强治疗结果至关重要.

研究的目的:

开发和评估基于体的新型纳米系统 (DPP IR Mtx @Lipo NPs) 用于乳腺癌的联合化疗和光热疗法.
研究作用机制,包括光热转换效率,药物释放和亡诱导.

主要方法:

氨酸,IR 775和米托克桑的自我组装成体纳米粒子 (DPP IR Mtx @Lipo NPs).
在体外评估光热转换效率,在NIR激光照射时的药物释放动力学,以及4T1乳腺癌细胞中的细胞毒性 (2D和3D模型).
对亡诱导,p53通路激活和线粒体破坏的评估.

主要成果:

DPP IR Mtx @Lipo NPs表现出高效的光热转化 (65.8%),并在NIR照射时触发了药物释放.
在4T1细胞中观察到显著的细胞亡和细胞死亡,健康细胞的损伤最小.
尼尔射线激光暴露诱导了组合光动力学/光热疗法,导致线粒体破坏和p53依赖的亡.

结论:

开发的DPP IR Mtx @Lipo NP是化学光热疗法的有效多功能纳米系统.
这些纳米粒子通过通过p53激活诱导亡,显示出针对性乳腺癌治疗的潜力.
这项研究强调了PDT/PTT和向药物输送的协同效应,以加强癌症废除.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.化学-光热疗法化学-光热疗法热量过高的情况.形体体是一种形体体.暂时的转变是暂时的转变.

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