卵巢刺激方案不会影响质积分或母细胞囊率
Mauro Cozzolino1, Laura Mossetti2, Giulia Mariani2
1IVIRMA Global Research Alliance, IVI Roma, Rome, Italy.; IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain..
Reproductive biomedicine online
|June 5, 2024
概括
总性腺激素剂量并没有影响试管婴儿的结果或形积分率. 然而,更年轻女性更高的人类更年期性淋巴腺素 (HMG) 剂量与较低的肺积分相关,这表明个性化治疗方法.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 遗传学 是一个遗传学.
背景情况:
- 外源性淋巴腺素在IVF中对受控的卵巢刺激至关重要.
- 淋巴激素剂量和类型对动脉积分和生殖结果的影响仍然是研究领域.
研究的目的:
- 为了调查总淋巴结素剂量 (<3000 IU或≥3000 IU) 和类型 (重组FSH,HMG) 是否会影响形和爆发率.
- 确定这些因素对试管婴儿生殖结果和累积活产率 (CLBR) 的影响.
主要方法:
- 这是一项回顾性,观察性,多中心的队列研究,对8466名接受试管婴儿治疗的患者进行了植入前遗传检测.
- 患者按总淋巴腺素剂量和母亲年龄分层.
- 分析了血管积分率,爆发率,妊娠结果和CLBR的分析.
主要成果:
- 总性腺激素剂量 (<3000 IU vs. ≥3000 IU) 并没有显著影响形,爆发或CLBR.
- 更高的人类更年期性淋巴腺素 (HMG) 剂量与较低的动脉积分率相关 (P=0.02),特别是在年轻女性 (P<0.001).
- 根据淋巴腺素剂量,没有观察到IVF结果或CLBR的显著差异.
结论:
- 总的淋巴腺素剂量似乎不会影响IVF中的阳性积分或生殖结果.
- 在年轻女性中,HMG的比例增加可能与减少的肺积分症有关.
- 淋巴激素和HMG的剂量并不直接先于形;HMG的使用应根据患者的特征和不孕症类型来个性化.
相关概念视频
02:07Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
01:27Ovarian Cycle
1.1K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.1K
01:57Meiosis II
183.3K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
183.3K
01:30Hormonal Control of the Ovarian Cycle
468
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
468