从塑料食品包装中转移内分泌和代谢破坏性化学物质
Sarah Stevens1, Zdenka Bartosova1, Johannes Völker2
1Norwegian University of Science and Technology (NTNU), Department of Biology, 7491 Trondheim, Norway.
Environment international
|June 5, 2024
概括
化学物质从塑料食品接触品 (FCAs) 中迁移,破坏内分泌和代谢功能. 这项研究分析了塑料的迁移,发现了广泛的核受体干扰,并确定了食品模拟剂中的潜在内分泌干扰化学物质.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
背景情况:
- 塑料中使用的化学物质超过16000种,其中数千种可提取,包括有毒物质.
- 这些化学物质从塑料食品接触用品 (FCAs) 迁移到食品和水中的情况尚不清楚.
- 人类接触这些迁移化学物质是一个重大问题.
研究的目的:
- 描述从塑料FCAs迁移的内分泌和代谢破坏活动.
- 确定来自各种塑料食品接触材料的迁移物质的化学成分.
- 评估与从塑料中浸出到食品中的化学物质相关的人类暴露的潜在风险.
主要方法:
- 在使用欧洲规定的水和水-乙醇混合物中迁移的规则下,测试了七种聚合物类型的14种塑料FCA.
- 记者基因测试被用来评估核受体活性 (内分泌和代谢中断).
- 使用非目标化学分析来描述迁徙者的化学成分.
主要成果:
- 所有分析的塑料FCA都显示了干扰至少两个核受体的迁移物,主要是孕妇X受体.
- 在多种迁徙动物中检测到雌激素和抗雄激素活性.
- 虽然比水与乙醇混合物更少地迁移到水中,但73%的可提取化学特征转移到食品模拟剂中,FCA之间的化学复杂性差异很大.
结论:
- 塑料FCAs释放内分泌和代谢破坏化学物质到食品模拟剂中.
- 这些活性化合物的迁移到食品和饮料是可能的,这可能会给健康带来潜在的风险.
- 进一步确定优先化学特征是必要的,以充分理解毒理学影响.
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