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Updated: Jun 24, 2025

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
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Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

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在一个被囚禁的婆罗洲猩猩 (Pongo pygmaeus) 中,全身AL卡帕链粉症

Susumu Iwaide1, Hitoshi Takemae2, Mami Oba2

  • 1Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, Japan.

Research in veterinary science
|June 5, 2024
PubMed
概括

系统性粉样蛋白轻链 (AL) 粉样蛋白症在猩猩中被发现. 蛋白质组分析证实了粉样沉积物中的免疫球蛋白卡帕轻链,揭示了对非人类灵长类动物疾病病原学的洞察力.

关键词:
在AL氨基粉症症.婆罗洲猩猩是什么意思?比较病理学比较病理学免疫球蛋白是卡帕链的组成部分.质谱测量质量谱测量赛车比赛 赛车比赛

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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