Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Drug Discovery: Overview01:26

Drug Discovery: Overview

7.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

1.9K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
1.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Optimization of colonoscope bedside precleaning protocol: an orthogonal experimental study.

Frontiers in cellular and infection microbiology·2026
Same author

Co-exposure to UV-328 and cadmium in radish: Interactive effects on uptake, translocation, and potential dietary risk.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Geographical patterns, sources, and ecological risks of short- and medium-chain chlorinated paraffins in mulching cultivated soils across China.

Journal of hazardous materials·2026
Same author

ROS-mediated membrane damage and antioxidant imbalance drive apple flesh browning during cold storage.

Frontiers in plant science·2025
Same author

Adaptation and Selection of Microbial Communities during Multiyear Biodegradable Plastic Mulching in Field Soils and Implications for Remediation.

Environmental science & technology·2025
Same author

Clinical outcomes of bowel preparation education strategies in colonoscopy: An evidence map of systematic reviews.

Medicine·2025
Same journal

NCP07: A potent ERα CBS-targeted degrader with dual-action against ESR1 mutations in breast cancer.

European journal of medicinal chemistry·2026
Same journal

Advances in selective inhibitors targeting the BD1 and BD2 domains of BET proteins.

European journal of medicinal chemistry·2026
Same journal

Development of potent BChE/Nrf2 modulators for Alzheimer's disease treatment via dual suppression of ferroptosis.

European journal of medicinal chemistry·2026
Same journal

Design, synthesis, and biological evaluation of HSP70-mediated HEMTACs as novel androgen receptor degraders.

European journal of medicinal chemistry·2026
Same journal

Design, synthesis, and anti-SARS-CoV-2 activity of vilazodone derivatives as METTL3 inhibitors.

European journal of medicinal chemistry·2026
Same journal

Fully synthetic arecoline and arecaidine vaccine candidates with α-Galactosylceramide as built-in adjuvant.

European journal of medicinal chemistry·2026
查看所有相关文章

相关实验视频

Updated: Jun 24, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

8.9K

针对GPX4向化合物的研究进展.

Bingru Li1, Keguang Cheng2, Tzumei Wang1

  • 1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.

European journal of medicinal chemistry
|June 5, 2024
PubMed
概括
此摘要是机器生成的。

向谷氨过氧化酶4 (GPX4) 途径诱导癌细胞通过铁灭亡死亡. 本综述详细介绍了直接针对GPX4的化合物,为癌症治疗提供了新的治疗策略.

更多相关视频

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

6.9K
A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
06:56

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

13.7K

相关实验视频

Last Updated: Jun 24, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

8.9K
Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

6.9K
A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
06:56

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

13.7K

科学领域:

  • 生物化学 生物化学
  • 在瘤学瘤学.
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 系统Xc-/谷氨/GPX4通路对于细胞生存至关重要.
  • GPX4是铁亡的关键调节者,是一种编程细胞死亡的形式.
  • 准GPX4为癌症治疗提供了一个新的策略.

研究的目的:

  • 审查直接针对GPX4蛋白质的化合物.
  • 探索GPX4的抑制剂,激活剂和降解剂.
  • 讨论涉及GPX4向剂的组合疗法.

主要方法:

  • 在文献中搜索针对GPX4.4的化合物.
  • 基于其作用机制 (抑制剂,激活剂,降解剂) 的化合物的分类.
  • 对GPX4向剂和组合疗法的当前研究进行分析.

主要成果:

  • 已经确定了几类直接针对GPX4的化合物.
  • 这些包括小分子抑制剂,激活剂和新型降解剂 (小分子和模拟分子).
  • 组合疗法在增强抗瘤效果方面表现有前途.

结论:

  • 直接准GPX4是一种可行的策略,用于诱导癌细胞中的铁亡.
  • 对GPX4向化合物和组合疗法的进一步研究是有必要的.
  • 这种方法有可能开发新的癌症治疗方法.