皮质缺氧维持了对Candida albicans的殖民抵抗力
Hannah P Savage1, Derek J Bays2, Connor R Tiffany1
1Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
Cell host & microbe
|June 5, 2024
概括
抗生素的使用允许 Candida albicans 通过增加肠道氧气而过度生长. 通过酸盐或5-ASA恢复低氧水平,可以防止这种真菌繁殖,并保持肠道健康.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 抗生素治疗可以破坏肠道微生物群,导致机会性真菌的过度生长,如Candida albicans.
- 控制肠道抗生素后真菌繁殖的精确机制尚未完全理解.
- 氧气的可用性是影响肠道环境中的微生物生长和竞争的关键因素.
研究的目的:
- 研究氧气作为限制性资源在抗生素治疗后肠道Candida albicans扩张的作用.
- 阐明肠道微生物和宿主信号通路调节氧气水平并影响真菌殖民抵抗力的机制.
主要方法:
- 使用了用抗生素治疗的gnotobiotic小鼠模型.
- 评估了Candida albicans的生长和资源利用在体外和体内.
- 在盲肠和大肠中测量氧气水平.
- 研究了克洛斯特里迪亚物种,酸盐产生的作用,以及过氧体增殖器激活受体玛 (PPAR-γ) 信号的作用.
- 评估了5-氨基酸 (5-ASA) 和益生菌大肠杆菌对真菌殖民的影响.
主要成果:
- 菌需要氧气来利用简单糖来生长,这表明无氧生态会限制其在肠道中的扩张.
- 抗生素治疗减少了克洛斯特里迪亚,减少了酸盐,增加了上皮氧化,促进了C. albicans的繁荣.
- 用PPAR-γ激动剂5-ASA恢复上皮质缺氧可以防止抗生素后的C. albicans外生.
- 益生菌大肠杆菌的氧气呼吸也赋予了对C. albicans的殖民抵抗力.
结论:
- 有限的氧气供应是维持肠道中对Candida albicans的殖民性抵抗的一个关键因素.
- 克洛斯特里迪亚产生的丁酸盐和宿主PPAR-γ信号传递对于维持肠道缺氧和防止真菌繁殖至关重要.
- 向氧气水平是对抗抗生素诱导的真菌失生症的潜在治疗策略.
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