功能性脂质体对血脑屏障 (BBB) 透和脑准的PEG长度效应
Qiuli Du1, Yang Liu1, Mengyu Fan1
1Henan-Macquarie University Joint Centre for Biomedical Innovation, Henan Key Laboratory of Brain Targeted Bio-Nanomedicine, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
概括
聚乙烯甘醇 (PEG) 链长度对于脑向药物输送至关重要. 纳米颗粒上的更长的PEG链增强了血脑屏障的透和大脑积累,用于治疗大脑疾病.
科学领域:
- 纳米医学是一种纳米医学.
- 药物运输 药物运输 药物运输
- 神经科学是一个神经科学.
背景情况:
- 基化纳米颗粒显示出针对性脑药物输送的前景.
- 聚乙烯糖醇 (PEG) 链长度对血脑屏障 (BBB) 透和脑准的影响尚不清楚.
研究的目的:
- 为了研究各种PEG链长度 (2,3.4,5,10kDa) 对BBB透和Angiopep-2装饰脂质体的脑向的影响.
- 为了确定最佳的PEG长度,以有效地传递大脑.
主要方法:
- 使用的angiopep-2被装饰的脂质体具有不同的PEG链长度 (2,3.4,5,10kDa).
- 在体外通过内细胞酶和体外通过转细胞酶透BBB的评估细胞吸收.
- 在正常小鼠和带质母细胞瘤 (GBM) 的小鼠体内评估脑向和积累.
主要成果:
- 较短的PEG链在体外通过内细胞分裂增强了细胞吸收.
- 较长的PEG链在体外通过转细胞和体内针对大脑的BBB透率更高.
- 长链PEG修饰脂质体显示由于延长血液循环和增强BBB透,大脑积累增加.
结论:
- PEG链长度是影响BBB透和纳米颗粒对大脑准的关键因素.
- 较长的PEG链在体内大脑输送中更有效,为治疗脑疾病中的纳米载体设计提供了指导.
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