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Updated: Jun 24, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Published on: July 17, 2019

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在BRAF抑制剂的目标之外,会破坏内皮信号传递和血管屏障功能

Sophie Bromberger1, Yuliia Zadorozhna1, Julia Maria Ressler1

  • 1Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Life science alliance
|June 5, 2024
PubMed
概括

用于黑色素瘤的BRAF抑制剂可以悖论地激活血管细胞中的MAPK信号,导致某些药物但不是其他药物的障碍功能受损. 这揭示了BRAF抑制剂明显的内皮副作用.

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