血糖,脂质和BMI之间的时间关系及其对动脉样硬化的影响:一项前性队列研究
Shanshan Jin1,2, Junyi Liu2,3, Yubing Jia2
1Nutrition, Chengdu Women's and Children's Central Hospital, Chengdu, China.
BMJ open
|June 5, 2024
概括
血糖和脂质的变化影响身体质量指数 (BMI),影响动脉样硬化 (AS) 风险. 管理这些代谢因素对于早期AS预防和控制策略至关重要.
科学领域:
- 心血管疾病的研究研究.
- 代谢综合征研究研究
- 动脉样硬化病原体的产生
背景情况:
- 动脉样硬化 (AS) 是一个重要的心血管风险.
- 了解代谢因素和AS之间的相互作用对于预防至关重要.
- 血糖,脂质和体重指数 (BMI) 是主要的代谢指标.
研究的目的:
- 研究血糖,脂质和BMI之间的时间关系.
- 确定这些因素对发展动脉样硬化风险的影响.
- 阐明BMI在葡萄糖-脂质-AS路径中的调解作用.
主要方法:
- 未来的队列研究设计.
- 包括2659名年龄在20-74岁之间的参与者.
- 在基线和随访时测量禁食血糖 (FBG),2小时食后葡萄糖 (2小时PG),脂质 (TC,TG,LDL-c,HDL-c) 和BMI.
- 评估脚脉冲波速度 (baPWV) 作为AS风险标志物.
- 逻辑回归,交叉滞后路径分析和调解分析的应用.
主要成果:
- 增加的FBG,2小时PG,TC,TG,LDL-c和BMI与AS风险增加有关.
- 较高的HDL-c水平与AS风险降低有关.
- 基线血糖和脂质水平比基线BMI预测的随访血液参数更显著地预测了随访BMI.
- 调解分析显示,FBG,2小时PG,TC,TG和LDL-c通过增加BMI (LDL-c>TC>TG>FBG>2小时PG) 来增加AS风险.
- 增加的HDL-c通过降低BMI来降低AS风险.
结论:
- 血糖和脂质的代谢变化可以在BMI之前和影响BMI.
- 体重指数 (BMI) 在将血糖和脂质与AS风险联系起来的途径中起着调解作用.
- 这些发现强调了早期AS预防和管理的综合策略的重要性,这些策略既针对代谢参数,也针对BMI.
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