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新型两性PROTAC具有增强的药理动力学特性,用于ALK蛋白质降解

Shirui Wang1, Zhanzhan Feng1, Can Qu2

  • 1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.

Journal of medicinal chemistry
|June 5, 2024
PubMed
概括

这项研究开发了B1-PEG,一种新型的形形蛋白解向金像体 (PROTAC),可以提高水溶性和生物可用性. 在临床前模型中,B1-PEG显示出显著的瘤回归,为向癌症治疗提供了有前途的进展.

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