系统性阿扎胺剂对健康马的眼内压的影响-一项初步研究
Anat Shnaiderman-Torban1, Oren Pe'er1, Kajsa Gustafsson1,2
1Koret School of Veterinary Medicine (KSVM), The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Veterinary ophthalmology
|June 5, 2024
概括
在一周的治疗期间,口服乙胺在健康马群中显著降低了眼内压力 (IOP). 在停止碳酸酶抑制剂 (CAI) 后不久,内压恢复到基线水平.
科学领域:
- 兽医眼科医生 兽医眼科医生
- 马类药理学 马类药理学
背景情况:
- 局部碳酸酶抑制剂 (CAI) 是马类玻璃眼的标准.
- 口服乙醇胺是一种全身性CAI,用于马匹的高血性周期性.
- 关于口服乙胺对马类眼内压 (IOP) 的影响的数据有限.
研究的目的:
- 为了研究口服乙胺对马的IOP的影响.
- 评估马类动物口服乙醇胺的药理学概况.
主要方法:
- 十匹健康的马一周内每天两次接受口服乙胺 (4.4毫克/公斤).
- 用液体染色学/并联质谱法测量了血清中乙胺度.
- IOP在治疗前,治疗期间每天记录,并在治疗后长达72小时记录.
主要成果:
- 口服阿西塔佐拉米德的使用导致治疗第三天IOP显著下降.
- 在整个为期一周的治疗期间,内脏压力下降一直持续.
- 在停止治疗48小时后,观察到显著的内血压增加.
- 药理动力学分析显示,72小时后血清度达到稳定状态.
结论:
- 口服乙胺有效降低马匹的内压.
- 进一步的研究是有必要的,以探索其作为马类玻璃眼治疗剂的潜力.
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