状态,选择和感官集成编码在barrel皮层LII/III中的共存
Pierre-Marie Gardères1,2, Sébastien Le Gal3, Charly Rousseau3
1Institut Pasteur, Université Paris Cité, Unit of Neural Circuits Dynamics and Decision Making, F-75015, Paris, France. pmgarderes@gmail.com.
主要感官皮层可靠地表示感知刺激. 选择信号和刺激表征独立地变化,这表明下游地区处理决策的变化.
科学领域:
- 神经科学是一个神经科学.
- 感官感知是一种感官感知.
- 决策 决策 决策 决策
背景情况:
- 与选择相关的神经活动延伸到主要的感官区域.
- 选择信号与早期感官表现的对齐不清楚.
- 了解这种对齐对于解释前感知机制至关重要.
研究的目的:
- 研究主体体感官皮层 (wS1) 在感知决策中的作用.
- 确定早期感官表现如何与选择信号保持一致.
- 在wS1.1中探索刺激,选择和任务参与的神经编码.
主要方法:
- 在小鼠中使用振动刺激的双替代强制选择 (2AFC) 任务.
- 在wS1.1中对特定皮质柱进行光遗传性沉默.
- 在体内对II/III层神经元的功能成像.
主要成果:
- 光遗传沉默转移了心理测量功能,确认知觉依赖于焦点wS1表示.
- 神经元显示刺激,选择和任务参与的混合编码.
- 多胡须抑制增强了感官歧视和与任务参与相关的活动.
- 在不同试验中,刺激和选择的表现在直角上有所不同.
结论:
- 主要感官皮层为感知提供了一个稳定的感官基板.
- 感知变化很可能来自下游加工区,而不是wS1.
- wS1的活动支持灵活的下游决策流程.
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