国际空间站上的太空飞行改变了两名宇航员的骨肌肉蛋白质组
Marta Murgia1,2, Jörn Rittweger3,4, Carlo Reggiani5,6
1Department of Biomedical Sciences, University of Padova, 35131, Padua, Italy. mmurgia@biochem.mpg.de.
NPJ microgravity
|June 5, 2024
概括
太空飞行会在宇航员骨肌中造成显著的线粒体损伤. 反应性氧物种 (ROS),而不仅仅是卸载,可能是主要原因,运动可能会减轻损伤.
科学领域:
- 太空飞行和运动生理学
- 分子生物学和蛋白质组学
背景情况:
- 太空任务诱导骨肌肉缩和力量损失由于微重力和辐射.
- 之前的研究重点是对象蛋白,但线粒体和细胞外变化仍然不太了解.
研究的目的:
- 为了分析线粒体蛋白质组,细胞外基质和宇航员骨肌中的抗氧化剂反应的隔间解决变化.
- 研究反应性氧物种 (ROS) 与机械卸载在太空飞行引起的肌肉损伤中的作用.
- 探索飞行器上体育炼对太空飞行期间肌肉适应的影响.
主要方法:
- 在太空任务前后从宇航员的骨肌肉活检上,基于质谱学的蛋白质组学.
- 蛋白质组数据的比较分析,重点关注线粒体区,细胞外基质和抗氧化途径.
- 运动水平与观察到的分子变化之间的相关性分析.
主要成果:
- 显著下调线粒体蛋白质组,特别是内膜和矩阵蛋白质,在两个宇航员.
- 细胞外基质和抗氧化剂反应的分区解决重塑.
- 部分相反的表达趋势在自调节器和ROS清理器中,可能与炼水平相关.
结论:
- 太空飞行引起的骨肌肉线粒体损伤可能主要是由反应性氧物种 (ROS) 而不是机械卸载驱动的.
- 船上体育炼可以通过机械传导防止肌肉缩,并通过自和抗氧化剂反应改善线粒体质量控制.
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