修改的老年人营养风险指数在口腔状细胞癌的预后重要性
Yao-Te Tsai1,2, Ming-Hsien Tsai2,3, Geng-He Chang1,2
1Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Scientific reports
|June 5, 2024
概括
手术前修改的老年营养风险指数 (mGNRI) 预测了口腔状细胞癌 (OCSCC) 手术患者的结果. 更高的mGNRI得分与更好的整体存活率 (OS) 和无病存活率 (DFS) 相相关.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 老年医学 老年医学
背景情况:
- 口腔状细胞癌 (OCSCC) 是一个重要的全球健康问题.
- 预后标志物对于量身定制OCSCC治疗和改善患者结果至关重要.
- 营养状况越来越被认为是影响癌症预后的因素.
研究的目的:
- 调查手术前修改老年营养风险指数 (mGNRI) 与为OCSCC进行手术的患者的预后之间的关联.
- 为了确定mGNRI在预测生存结果中的最佳切割值.
- 开发一个基于mGNRI的总生存率 (OS) 预测的诺米图.
主要方法:
- 对333名经过手术的OCSCC患者的临床数据 (2008-2017年) 的回顾性分析.
- 使用包含C反应蛋白,实际体重和理想体重的经过验证的公式计算手术前mGNRI.
- 使用接收器操作特征 (ROC) 曲线分析,卡普兰-梅尔生存分析和考克斯比例危险模型.
主要成果:
- 最优的mGNRI切割值被确定为73.3.3.
- 与低mGNRI (<73.3) (p <0.001) 患者相比,高mGNRI (≥73.3) 患者的5年OS和DFS率显著更高 (p <0.001).
- 手术前的mGNRI低于73.3是不利的DFS和OS的独立预测因素. 一个名ogram 实现了 0.781 的一致性指数 OS 预测.
结论:
- 手术前的mGNRI是OCSCC患者接受手术的有价值,具有成本效益的预后生物标志物.
- 开发的基于mGNRI的nomogram提供了准确和个性化的OS预测.
- 将mGNRI整合到临床实践中可以帮助OCSCC的风险分层和个性化管理.
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