在日本2型糖尿病患者中,范围内的时间与胰岛素分泌能力之间的关联
Kenichi Tanaka1, Yosuke Okada1, Fumi Uemura1
1First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Scientific reports
|June 5, 2024
概括
通过C-免疫反活性 (CPR) 指数测量胰岛素分泌能力,与2型糖尿病 (T2DM) 患者的改善时间范围 (TIR) 有关. 一个CPR指数为1.88或更高是最佳的预测更好的TIR.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 糖尿病管理 糖尿病管理
背景情况:
- 胰岛素分泌受损是2型糖尿病 (T2DM) 的标志,往往导致血糖变化.
- 剩余胰岛素分泌能力和血糖控制指标 (如时间范围 (TIR)) 之间的关系在T2DM中仍未得到充分研究.
研究的目的:
- 研究T2DM患者的胰岛素分泌能力和TIR之间的关联.
- 确定一个潜在的生物标志物来评估与TIR相关的胰岛素分泌能力.
主要方法:
- 对330名接受糖尿病教育的T2DM患者进行了回顾性分析.
- 利用间歇扫描的连续血糖监测 (isCGM) 并测量了禁食血清C-免疫活性 (S-CPR).
- 计算了S-CPR指数 (S-CPR [ng/mL]/空腹血葡萄糖 [mg/dL] × 100),并进行了多变量和ROC分析.
主要成果:
- TIR与S-CPR指数有显著的相关性 (TIR平均值为60.3%,S-CPR指数平均值为1.6).
- 多变量分析证实S-CPR指数是与TIR>70%相关的重要因素,与HbA1c和比瓜尼德使用一起.
- 确定1.88的S-CPR指数是预测TIR≥70%的最佳门.
结论:
- 根据S-CPR指数显示的胰岛素分泌能力与日本T2DM患者的TIR显著相关.
- 在TIR的背景下,S-CPR指数显示出作为评估胰岛素分泌能力的有用生物标志物的潜力.
- 这些发现表明,保持或改善胰岛素分泌可能对于在T2DM中实现最佳血糖控制至关重要.
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