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与cuproptosis相关的lncRNA签名作为扩散大B细胞淋巴瘤的预后工具和治疗点
Xiaoran Bai1,2, Fei Lu1, Shuying Li1
1Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Scientific reports
|June 5, 2024
概括
这项研究确定了七种与cuproptosis相关的长非编码RNA (lncRNAs),可预测扩散性大B细胞淋巴瘤 (DLBCL) 的预后. 开发的风险模型有助于理解DLBCL进展和潜在的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞死亡研究 细胞死亡研究
背景情况:
- 质亡是一种新的细胞死亡途径,涉及线粒体呼吸.
- 长非编码RNAs (lncRNAs) 与癌症的发展和传播有关.
- 与cuproptosis相关的lncRNAs在扩散性大B细胞淋巴瘤 (DLBCL) 病原发生中的作用尚不清楚.
研究的目的:
- 在DLBCL中识别与cuproptosis相关的lncRNAs的预后特征.
- 为DLBCL患者的预测结果开发一个预测模型.
- 探索与这些lncRNAs相关的分子功能和免疫景观.
主要方法:
- 利用来自TCGA和GEO的DLBCL患者的RNA-Seq数据.
- 使用皮尔森相关性分析选与cuproptosis相关的lncRNAs.
- 应用单变量考克斯,拉索和多变量考克斯回归来识别签名.
- 执行了GO,KEGG,ssGSEA,ESTIMATE和WGCNA用于功能和免疫分析.
- 进行药物敏感性分析.
主要成果:
- 鉴定了七个关键的与cuproptosis相关的lncRNAs (LINC00294,RNF139-AS1,LINC00654,WWC2-AS2,LINC00661,LINC01165,LINC01398). 发现了与cuproptosis相关的7个关键的lncRNAs (LINC00294,RNF139-AS1,LINC00654,WWC2-AS2,LINC00661,LINC01165,LINC01398). 发现了与cuproptosis相关的7个关键的lncRNAs (LINC00294,RNF139-AS1,LINC00654,WWC2-AS2,LINC00661,LINC01165,LINC01398). 发现了与cuproptosis相关的7个关键的lncRNAs.
- 开发了一个风险模型,其中高风险得分与DLBCL中较短的存活率相关.
- 该模型在预后能力方面表现优于传统的临床特征.
- 高风险组表现出免疫抑制细胞的增加和代谢,炎症和免疫通路的丰富.
- 在高风险组中注意到对维诺雷尔宾和甲胺的敏感性.
结论:
- 对于与cuproptosis相关的基因而言,一种新的七个lncRNA签名可以预测DLBCL的预后.
- 这种签名提供了对瘤微环境和免疫状态的见解.
- 这些发现表明DLBCL管理的潜在治疗点和药物敏感性.
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