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对1,3-丁的更高暴露与更严重的听力损失有关

Sang-Yoon Han¹, Sang-Yeon Lee^2,3, Myung-Whan Suh^2,3

¹Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Scientific reports

|June 5, 2024

概括

挥发性有机化合物 (VOC) 与听力损失 (HL) 有关. 特定的VOC代谢物,如DHBMA,与HL和高频听力损失 (HFHL) 有显著的关联,表明需要减少暴露.

科学领域:

环境健康环境健康
听力学听力学是指听力学.
毒理学毒理学毒理学

背景情况:

已知挥发性有机化合物 (VOC) 会影响各种器官.
挥发性有机物对听力损失 (HL) 的影响仍未得到充分研究.
高频听力损失 (HFHL) 是一种常见的听力损失类型.

研究的目的:

调查VOC代谢物与HL或HFHL之间的关联.
确定可能导致听力损失的特定VOCs.
了解VOC暴露与听觉健康之间的关系.

主要方法:

利用了第八届韩国国家健康和营养调查的数据.
分析了纯音调听力测量,人口统计信息和高血压数据.
测量了与肌素纠正的尿液VOC代谢物度.

主要成果:

N-乙-S-基) -L-氨酸 (BMA),N-乙-S-基) -L-氨酸 (SPMA) 和N-乙-S-基 (3,4-二基) -L-氨酸 (DHBMA) 与HL相关.
HFHL显示与BMA,3和4-甲基希普酸 (3,4MHA),曼德利酸 (MA),SPMA,N-乙-S-(3-基) -L-氨酸 (3-HPMA) 和DHBMA有显著的关联.
在控制其他因素后,DHBMA与平均听力水平和高频听力水平都表现出线性关联.

结论:

特定的VOC代谢物,特别是DHBMA,与听力损失有显著的关联.
1,3-丁是一种潜在的耳毒物质,需要注意暴露控制.
对暴露于1,3-丁的工人进行早期查和减少环境暴露可能有助于预防听力损失.

关键词:

环境污染物环境污染物高频听力损失是一种高频的听力损失.噪声噪声噪声感官神经神经听力损失是什么挥发性有机化合物挥发性有机化合物

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