循环瘤细胞数量的纵向分析改善了对转移性乳腺癌进展的跟踪
Malgorzata Szostakowska-Rodzos1, Anna Fabisiewicz1, Maciej Wakula1
1Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Scientific reports
|June 5, 2024
概括
在转移性乳腺癌 (mBC) 中监测循环瘤细胞 (CTC) 提供预后价值. 随着时间的推移跟踪CTC动态和遗传变化,为疾病进展和治疗耐药性提供了关键的见解.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
背景情况:
- 激素反应性乳腺癌很常见,但远程转移显著降低了生存率.
- 监测转移性乳腺癌 (mBC) 进展对于患者管理至关重要.
- 循环瘤细胞 (CTC) 显示出诊断潜力,但缺乏确定的预后价值.
研究的目的:
- 评估循环瘤细胞 (CTC) 数量及其在晚期乳腺癌中的动态的预后价值.
- 与初级瘤相比,评估CTCs中的分子变化,重点关注与内分泌治疗耐药性相关的基因.
- 确定CTC遗传分析是否可以追踪耐药性并指导治疗决策.
主要方法:
- 对135名转移性乳腺癌患者进行了长度研究,并进行了三次连续血液采集.
- 使用EpCAM独立的CytoTrack系统检测和隔离循环瘤细胞 (CTC).
- 用下一代测序 (NGS) 分析单独的CTC用于突变分析.
主要成果:
- CTC状态对无进展和整体存活具有重要意义.
- 对CTC动态的纵向监测在预测临床进展方面比单次计数提供了优势.
- 在CTC中,高遗传和表型异质性表明异异的转移性病变和潜在的早期传播.
结论:
- 持续监测CTC及其动态对于管理晚期乳腺癌至关重要.
- 观察到的CTC异质性凸显了转移性疾病的复杂性.
- 这项研究没有证实CTC激活突变的趋势,导致抗雌激素耐药性.
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