整合系统生物学和内基因疗法,通过转补适当的共刺激分子作为瘤性疹病毒有效载荷

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Updated: Jun 24, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

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A Finizio1,2, P Pagano1,2, A Napolano1,2

  • 1Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131, Napoli, NA, Italy.

Cancer gene therapy
|June 5, 2024
PubMed
概括

我们设计了一种致癌病毒,以增强癌症免疫疗法. 这种武装的病毒,向可诱导的共刺激器连接体 (ICOSL),显著改善了瘤控制和激活的T细胞,支持组合疗法.

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