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在年轻人中探索神胺摄入量和肝硬化症之间的关联
Yi Kong1, Li Han2, Zhongxin Zhu3
1Department of Pharmacy, The First People's Hospital of Xiaoshan District, 311200, Hangzhou, Zhejiang, People's Republic of China.
Scientific reports
|June 5, 2024
概括
在年轻人中,较高的神胺摄入量与较不严重的脂肪肝有关. 特定的摄入水平可能会使黑人美国人受益,这表明针对非酒精性脂肪肝疾病 (NAFLD) 预防的个性化营养.
科学领域:
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪肝 (NAFLD) 的发病率在年轻人群中正在增加.
- 在脂肪肝疾病的发展或进展中,饮食中的神胺的具体作用仍然在很大程度上未被描述.
研究的目的:
- 调查饮食中的神胺摄入量与肝脏肥胖症程度之间的关联.
- 通过使用国家健康调查数据,分析45岁及以下的个体之间的这种关系.
主要方法:
- 利用了2017-2020年国家健康和营养检查调查 (NHANES) 的数据,其中包括1796名45岁以下的参与者.
- 采用肝脏超声波过渡性弹性图,以评估肝脏肥胖症 (控制衰减参数 - CAP).
- 进行多变量回归,子组分析和非线性建模 (一般化添加模型,两部分线性回归) 来检查关联,调整混因素.
主要成果:
- 经过对混因素进行调整后,较高的神胺摄入量与较低的CAP值 (较少的肝硬化) 有显著的关联.
- 在18-45岁的个人,女性和白人群体中观察到显著的负相关性.
- 在黑人美国人中发现了一个U形关系,在每天摄入约44.5毫克神胺时,肝脏肥胖症是最佳的.
结论:
- 饮食中较高的理论胺摄入量与年轻人,特别是女性和白人群体的肝硬化程度降低有关.
- 特定的胺摄入量 (约44.5毫克/天) 可能有助于最大限度地减少黑人美国人的肝硬化症.
- 这些发现支持个性化的营养指导和潜在的治疗策略,以预防和管理年轻人的NAFLD.
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