在猪中表征肠道体和体传播的抗菌素耐药性基因
Jun Hu1,2,3,4, Jianwei Chen5,6, Yangfan Nie1,2
1National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
Microbiome
|June 5, 2024
概括
这项研究揭示了七种猪品种的多样化肠道菌体,确定了关键菌体家族及其在感染各种细菌中的作用. 猪肠菌体是抗菌素耐药性基因的重要储存库.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 动物科学动物科学
背景情况:
- 哺乳动物肠道菌体对于微生物生态系统和宿主健康至关重要.
- 猪是重要的生物医学模型和食物来源,但它们的肠菌体知识有限.
研究的目的:
- 为了研究七种猪品种的肠道菌群.
- 描述猪肠菌体的多样性,功能和抗菌素耐药性基因携带.
主要方法:
- 在112头猪的基因组数据上使用了PhaBOX策略.
- 组装和分类了近175,000个非冗余的肠道菌体基因组.
- 分析了菌体社区结构,宿主范围和功能基因含量.
主要成果:
- 确定了33,487种被分类为肠道菌体,主要来自阿克曼病毒,斯特拉博病毒和佩杜病毒家族.
- 观察到不同的菌体群落,根据猪品种和年龄而异.
- 发现了感染212种 prokaryotic 属的菌体,并携带广泛的 KEGG / CAZy 功能,包括丰富的抗菌素耐药性基因 (ARG).
结论:
- 在七种猪品种中描绘了肠道菌体的景观.
- 已建立的猪肠菌体作为抗菌素耐药性基因 (ARG) 的关键储存库.
相关概念视频
00:57Antibiotic Selection
53.1K
Overview
53.1K
00:46Genomic DNA in Prokaryotes
43.8K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.8K