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变系数对双相情感障碍患者发作风险的影响:试点研究
Saniye Başak Oktay1, Şeyma Sehlikoğlu2, Sevler Yildiz3
1Department of Biochemistry, Faculty of Medicine, Alanya Alaaddin Keykubat University, Alanya, Antalya, Turkey.
Annals of clinical biochemistry
|June 6, 2024
概括
用变化系数 (CV) 测量的水平波动与增加双相情感障碍发作风险有关. 监测心血管可能会改善预测和患者护理.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 双极性障碍的治疗依赖于维持治疗性血清水平.
- 疗法旨在稳定情绪并预防发作.
- 水平的变化可能会影响治疗疗效和患者的治疗结果.
研究的目的:
- 调查水平变化 (变化系数,%CV) 与双相情感障碍患者的发作风险之间的关联.
- 为了确定%CV是否能预测未来的情绪情节.
- 探索%CV与发作频率之间的关系.
主要方法:
- 从2018-2022年对75名双相情感障碍患者的回顾性评估.
- 纳入标准:≥2年随访,≥3年水平在治疗范围内.
- 计算平均水平,标准偏差 (SD) 和%CV;按发作状态进行分类.
主要成果:
- 最近发作的患者显示显著更高的SD和%CV的水平 (P <.05).
- 接收器操作特征 (ROC) 分析表明%CV (AUC=0.722) 和SD (AUC=0.709) 可以预测事件.
- 17.39的最佳%CV截止值显示了67%的敏感性和69%的特异性;%CV和发作数之间存在弱相关性 (r=0.376).
结论:
- 显著的水平波动 (%CV) 与双相情感障碍患者最近的发作有关,尽管治疗平均水平.
- 将%CV整合到常规监测中可能会增强双相情感障碍的临床评估.
- 监测%CV可以改善预测和个性化治疗策略.
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