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由于母亲的哈西莫托甲状腺炎引起的不寻常的先天:一个病例报告

Laura Català¹, Judit Casas¹, Sean Yeh¹

¹Department of Pediatrics, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Frontiers in pediatrics

|June 6, 2024

概括

遗传性甲状腺功能低下 (CH) 是常见的,但肠是罕见的. 这一案例突出了一个新生儿由于母亲的抗甲状腺过氧化酶抗体 (TPOAb) 产生的先天,并成功地用Levothyroxine治疗.

科学领域:

儿科内分泌学儿科内分泌学
新生儿医学新生儿医学
免疫学免疫学免疫学

背景情况:

先天性甲状腺功能低下症 (CH) 是最常见的新生儿内分泌病.
kongenital goiter 是 CH 的一种罕见表现.
新生儿自身免疫性甲状腺功能低下症非常罕见.

研究的目的:

报告一例罕见的新生儿先天性喉和甲状腺功能低下症.
研究母亲抗甲状腺过氧化酶抗体 (TPOAb) 在新生儿甲状腺功能障碍中的作用.
描述这种情况的管理和结果.

主要方法:

一个新生男婴患有先天性肠的案例报告.
在母亲的病史中出现了哈西莫托甲状腺炎.
新生儿实验室评估包括自由甲状腺素,甲状腺刺激激素和TPOAb水平.
开始使用Levothyroxine的治疗.

主要成果:

新生儿出现了3级子和实验室确认的甲状腺功能低下症 (低自由T4,高TSH).
检测到高的母体TPOAb水平,这表明体外抗体转移.
在生命的第二天开始的levothyroxine治疗导致甲状腺功能正常化.

结论:

母亲的高TPOAb水平很少会导致新生儿的先天性肠和甲状腺功能低下症.
早期诊断和使用Levothyroxine的治疗对于正常的神经发育至关重要.
这一案例强调了在怀孕期间监测母亲甲状腺状况的重要性.

关键词:

这是自抗体的自抗体.出生性甲状腺功能低下症 (CH)子是一种子.甲状腺功能低下症甲状腺功能低下症新生儿新生儿的新生儿

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