照顾性别发育差异的人的背景:实验室例行中仍然缺少多样性
Alexandra E Kulle1, Martina Jürgensen2, Ulla Döhnert2
1Campus Kiel/Christian-Albrechts University of Kiel Division of Pediatric Endocrinology and Diabetes, Department of children and adolescent medicine I, University Hospital of Schleswig-Holstein Rosalind-Franklin-Str 9 24105 Kiel Germany.
2006年芝加哥共识声明改善了对性发育障碍 (DSD) 的护理. 然而,目前的临床实践和实验室测量仍然依赖于二进制系统,忽视了DSD多样性.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
- 儿科 儿科 儿科
背景情况:
- 2006年芝加哥共识声明为性别发育障碍/性别差异 (DSD) 提供了先进的临床管理.
- 最近对理解性和性别的社会转变为DSD护理带来了新的挑战.
- 医生面临着不断变化的环境,需要更新DSD诊断和治疗的方法.
研究的目的:
- 为医生提供当前DSD护理背景的概述.
- 突出由不断演变的性别/性别范式产生的特定临床挑战.
- 检查诊断和实验室测量对DSD管理的影响.
主要方法:
- 审查DSD管理中的临床实践挑战.
- 对诊断标准和实验室测量影响的分析.
- 讨论激素治疗中的二元系统和参考间隔的局限性.
主要成果:
- 实验室测量和荷尔蒙疗法仍然基于二元性别系统.
- 缺乏对各种DSD形式的特定参考间隔导致忽视了个别变异.
- 当前的做法可能无法充分解决DSD演示的范围.
结论:
- 实验室测量和激素治疗中的二元系统在DSD护理中构成了重大挑战.
- 需要更新的参考间隔,承认DSD多样性.
- 解决这些挑战对于改善患者护理和尊重DSD的个体差异至关重要.
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