在伊朗北部对毒素菌和活跃结核病的共感染进行血清流行病学研究:一个病例控制研究
Reza Jafari-Shakib1, Abbas Sadeghi2, Bijan Majidi-Shad2
1Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
概括
与结核病 (TB) 和Toxoplasma gondii (T. gondii) 的同时感染是常见的. 这项研究发现,在伊朗的结核病患者和健康人群中,T. gondii感染的患病率相似,这表明这两种感染之间存在独立性.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 和寄生虫感染的同时感染在发展中国家很普遍.
- 关于伊朗结核病患者中Toxoplasma gondii (T. gondii) 患病率的数据有限.
研究的目的:
- 与伊朗的健康对照人群相比,研究活跃结核病患者中T. gondii感染的血清流行率.
- 评估T. gondii感染和活跃结核病之间的关系,并确定潜在的风险因素.
主要方法:
- 一项涉及100名活跃结核病患者和100名健康对照者的病例控制研究,对人口统计学进行了匹配.
- 使用ELISA方法检测抗毒素淋巴菌IgG和IgM抗体.
主要成果:
- 在结核病患者 (62%) 和对照人群 (70%) 之间,T. gondii血清流行率没有显著差异.
- 结核病患者的抗T. gondiiIgG抗体度显著更高,表明幽默免疫反应更强.
- 没有社会人口统计学或行为因素被确定为结核病患者中毒素菌的危险因素.
结论:
- 在伊朗,T. gondii感染很普遍,并且独立于活性结核病发生.
- 虽然同时感染很常见,但T. gondii感染似乎不是这一群体中活跃结核病的重要风险因素或后果.
- 结核病患者对T. gondii. 呈现出较高的幽默免疫反应.
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