2型糖尿病中的维生素D缺乏和炎症标志物:大数据洞察力
Rujie Shan1, Qi Zhang1, Yusen Ding2
1Weifang Medical University, Clinical Medical, Weifang, 261000, China.
Open life sciences
|June 6, 2024
概括
维生素D缺乏症在2型糖尿病患者中很常见. 低维生素D水平与较高的炎症标志物相关,这表明维生素D状态和与糖尿病相关的炎症之间存在联系.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 维生素D缺乏是一个全球性的健康问题.
- 2型糖尿病与慢性炎症有关.
- 维生素D在2型糖尿病发病过程中的作用需要进一步研究.
研究的目的:
- 为了确定2型糖尿病患者中维生素D缺乏或不足的患病率.
- 探索维生素D水平与炎症标志物之间的关联.
- 调查维生素D与2型糖尿病中的代谢参数之间的关系.
主要方法:
- 在2,806名2型糖尿病患者 (≥30岁) 中测量了血清25-基维生素D3水平.
- 收集和分析了人口统计,病史,血脂,HbA1c和炎症标志物的数据.
- 使用了统计分析,包括趋势测试和多重线性回归.
主要成果:
- 观察到维生素D缺乏的高患病率,特别是在女性患者中.
- 男性的血清中位25(OH) D3水平为22.46 ng/mL,女性为19.00 ng/mL.
- 较低的维生素D水平与炎症标志物 (hsCRP,ESR,WBC,中性粒细胞,单细胞) 的增加有关,与高密度脂蛋白胆固醇负相关,与甘油三和HbA1c正相关.
结论:
- 维生素D缺乏或不足在2型糖尿病患者中很普遍.
- 低维生素D水平与系统性炎症的升高显著相关.
- 这些发现凸显了维生素D状态在管理2型糖尿病及其炎症并发症方面的潜在重要性.
更多相关视频
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
10.7K
10:34Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death
Published on: December 21, 2016
6.4K
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Diabetes: Symptoms, Diagnosis, and Complications
523
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
523
Carbohydrate Metabolism
11.0K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.0K
Psychoneuroimmunology: Diabetes and Cancer
28
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
28
Role of Skin in Vitamin D Synthesis
5.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.1K
