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Fixation and Operational Method for Abdominal Massage in T2DM Mice
Published on: March 7, 2025
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在2型糖尿病患者中,DTI-ALPS指数下降
Shuncheng Yu1, Hongjun Jiang1, Langxuan Yu1
1Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Frontiers in neuroscience
|June 6, 2024
概括
2型糖尿病 (T2DM) 与较低的ALPS指数有关,这是大脑白质量的衡量指标. 这种减少与认知功能相关,突出显示T2DM的潜在神经影响.
科学领域:
- 神经成像是一种神经成像.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2DM) 是一个日益增长的全球健康挑战,具有广泛的器官系统影响.
- 神经系统并发症和认知能力下降在T2DM患者中越来越多.
- 扩散张力成像 (DTI) 提供了对白质完整性的洞察.
研究的目的:
- 为了评估使用DTI-ALPS的T2DM患者的纵向放松时间变化 (ALPS) 指数.
- 调查ALPS指数与T2DM认知表现之间的相关性.
- 探索ALPS指数和T2DM中的扩散参数之间的关系.
主要方法:
- 招募了41名T2DM患者和27名健康对照 (HC).
- 进行了MRI扫描,认知评估 (MoCA) 和实验室测试.
- 使用基于路径的空间统计 (TBSS) 和通用线性模型 (GLM) 进行分析,包括斯皮尔曼和部分相关性.
主要成果:
- 与HC相比,T2DM患者的ALPS指数明显较低.
- ALPS指数与蒙特利尔认知评估 (MoCA) 成绩有显著的相关性.
- T2DM患者的平均扩散率 (MD) 和辐射扩散率 (RD) 增加,分数异性质 (FA) 降低.
结论:
- 在T2DM患者中,ALPS指数降低.
- 降低ALPS指数与T2DM患者的认知功能受损有关.
- DTI-ALPS可以作为T2DM神经变化的潜在生物标志物.
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