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皮质灰色物质体积的变化与认知导向对日常职业绩的干预在患有发育协调障碍的儿童中进行干预

Myrah Anum Malik¹, Alexander Mark Weber^2,3, Donna Lang^2,4

¹Graduate Programs in Rehabilitation Science, University of British Columbia, Vancouver, BC, Canada.

Frontiers in human neuroscience

|June 6, 2024

概括

对日常职业表现的认知导向 (CO-OP) 干预导致DCD儿童皮质灰质减少. 这些大脑变化表明成熟度增加并支持神经可塑性,尽管在本研究中与运动技能的改善没有直接联系.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
职业疗法职业疗法职业疗法

背景情况:

对日常职业表现的认知导向 (CO-OP) 是对患有发育协调障碍 (DCD) 的儿童推的干预措施.
以前的研究表明,CO-OP诱导了大脑的结构和功能变化,包括大脑小脑灰质的增加.
目前的研究调查了CO-OP对DCD儿童皮质灰质体积的影响.

研究的目的:

确定CO-OP干预是否会导致DCD儿童皮质灰质体积的变化.
评估这些灰质变化是否与运动性能和运动质量的改善相关.
为了解在DCD中CO-OP干预后的神经可塑性做出贡献.

主要方法:

一个随机的等候名单对照试验 (NCT02597751) 涉及78名患有DCD的儿童.
在6个月内进行了三次MRI扫描;治疗组的第一和第二次扫描之间进行了CO-OP干预.
基于voxel的形态测量 (VBM) 用于皮质灰色物质体积测量;性能质量评分尺度 (PQRS) 和Bruininks-Oseretsky运动能力测试-2 (BOT-2) 用于行为结果.

主要成果:

在CO-OP干预后,在右上额头和中间/后侧环状中观察到灰质体积的显著减少.
在灰质体积变化和PQRS (运动质量) 或BOT-2 (运动性能) 评分之间没有发现显著的关联.
分析组合组 (N=20) 由于排除后的样本大小限制.

结论:

在CO-OP后皮质灰质体积的减少表明大脑成熟度提高,并可能增加突触修剪.
观察到的自我调节和运动控制区域的变化与之前关于CO-OP神经可塑性影响的发现一致.
这项研究增加了CO-OP在促进发育大脑中积极的神经可塑性变化的作用的证据.

关键词:

合作社 (CO-OP) 是一个合作社.这就是为什么MRI是MRI.大脑结构大脑结构孩子们的孩子们的孩子们的孩子们.发育协调器障碍发育协调器障碍运动技能障碍运动技能障碍康复康复康复康复康复康复基于voxel的形态测量方法

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