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双杆菌长 (Bifidobacterium longum) 的亚种. 在成长中的小鼠中,infantis通过JAK-STAT通路调节Th1/Th2平衡

Mengfan Ding^1,2, Bowen Li^1,2, Haiqin Chen^1,2

¹State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, Jiangsu, China.

Microbiome research reports

|June 6, 2024

概括

某些Bifidobacterium longum亚种的一些菌株. 在婴儿小鼠中,infantis可以调节T助手 (Th) 1 / Th2免疫平衡. 这种益生菌补充剂可能有助于预防早期的免疫相关疾病.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

双细菌长子物种. 婴儿是婴儿健康的关键肠道细菌.
保持平衡的T助手 (Th) 1 / Th2免疫反应对于婴儿发育和疾病预防至关重要.

研究的目的:

研究八种不同的B. longum亚种的免疫调节作用. 婴儿科的菌株.婴儿科的菌株.
评估这些菌株对婴儿小鼠Th1/Th2平衡和肠道微生物群组成的影响.

主要方法:

有八种B. longum亚种. 在BALB/C小鼠中使用了infantis菌株,小鼠年龄为1至3周.
分析了免疫细胞种群,细胞因子水平 (IFN-γ,IL-4),免疫球蛋白 (IgG2a,IgE) 和肠道微生物群.
使用流式细胞计,ELISA和16S rRNA基因测序.

主要成果:

特定的菌株 (I4MI,I8TI,B6MNI) 调节了IgG2a/IgE比率,表明向Th1免疫转变.
在雌性和雄性小鼠中,B6MNI增加了IFN-γ和IgG2a水平,并降低了IL-4,也调节了JAK/STAT通路.
某些菌株 (I4MI,I5TI,B6MNI,I8TI) 增加了Bifidobacterium和B. longum亚种的丰度. 在肠道中的婴儿.

结论:

补充特定的B. longum亚种. 婴儿期早期的Infantis菌株可以调节Th1/Th2免疫平衡.
这种免疫调节可能是预防婴儿免疫相关疾病的策略.

关键词:

双细菌长子物种. 婴幼儿的孩子们在JAK/STAT路径中.在 Th1/Th2 余额中.双细菌的社区是双细菌.我们的肠道微生物群.

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