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结核淋巴腺炎确诊病例中的细胞形态学发现

Sana Ahuja¹, Rakesh Behera¹, Aarti Kumari¹

¹Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

|June 6, 2024

概括

精细针吸收细胞学是有效的诊断结核淋巴腺炎,与上皮质颗粒瘤和亡是常见的发现. 然而,通过Ziehl-Neelsen染料检测酸快细菌在这些情况下显示出有限的灵敏度.

科学领域:

病理学病理学病理学
微生物学微生物学
传染性疾病传染性疾病

背景情况:

结核病 (TB) 是一个重要的全球卫生问题,特别是在发展中国家.
精细针吸收细胞学 (FNAC) 是结核淋巴腺炎的主要诊断工具,因为它易于使用,侵入性最小,速度快,成本效益高.
结核病的特征性细胞病理特征包括带有兰翰斯巨细胞的表皮细胞颗粒瘤和病变性亡.

研究的目的:

评估新诊断的结核淋巴腺炎的细胞形态特征.
为了将细胞学发现与GeneXpert结核病确认相关联.

主要方法:

一项回顾性研究包括从新诊断的结核淋巴腺炎病例的细针吸入物,由GeneXpert在一年内确认.
涂抹用梅-格鲁诺瓦尔德-吉姆萨染色,并根据细胞形态学模式分类:有缩的上皮质颗粒瘤,没有缩的上皮质颗粒瘤和仅缩的上皮质颗粒瘤.
分析了颗粒瘤形态 (形成良好,形成不良,分裂) 和背景细胞性 (淋巴细胞,中性粒细胞,乙素细胞,反应性淋巴细胞).

主要成果:

带有缩的表皮质粒瘤是最常见的模式 (67.5%).
在Ziehl-Neelsen染色上,酸快细菌 (AFB) 的阳性为53.3%.
中性粒细胞 (35%) 和淋巴细胞 (30%) 是主要的背景细胞.

结论:

FNAC是一种快速,经济和最少的侵入性方法来诊断结核淋巴结核炎,而颗粒瘤和病状亡是结核病的高度暗示.
使用Ziehl-Neelsen染料手动检测AFB显示出低灵敏度,这一研究中仅53.3%的阳性结果证明了这一点.

关键词:

皮质状颗粒瘤皮质状颗粒瘤细针吸收细胞学精细针吸收细胞学淋巴腺炎是一种淋巴腺炎.尸体消亡 (necrosis) 是一种致死症.结核病结核病结核病结核病结核病

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