在接受泛FGFR抑制剂治疗的青春期前儿童的骨过度生长
Fataneh Majlessipour1, Gaohui Zhu2,3, Nicole Baca1
1Pediatric Hematology and Oncology, Cedars-Sinai Guerin Children's and Cedars-Sinai Cancer, Los Angeles, CA, 90048, USA.
Heliyon
|June 6, 2024
概括
纤维细胞生长因子受体 (FGFR) 抑制剂在患有质瘤的儿童中引起了意想不到的骨过度生长. 胰岛素样生长因子1 (IGF-1) 激活了生存途径,促进了治疗FGFR抑制剂的儿科患者的生长.
科学领域:
- 在瘤学瘤学.
- 儿科瘤学 儿科瘤学
- 分子生物学分子生物学
背景情况:
- 纤维细胞生长因子 (FGF) 和它们的受体 (FGFR) 在人类发育和癌症中起着至关重要的作用.
- FGFR抑制剂对具有体质FGFR突变的成年瘤有效.
- 对于FGFR抑制剂的儿科试验正在进行中,显示了一些积极的反应.
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