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TNFRSF4表达的预后意义和病理学模型的开发,以预测肝细胞癌表达

Zhaoyong Yan¹, Xiang Li², Zeyu Li³

¹Department of Interventional Radiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.

|June 6, 2024

概括

瘤坏死因子受体超级家族4 (TNFRSF4) 成员的表达和一种新的病理学模型显示为肝细胞癌 (HCC) 存活率的预后标志物具有前景. 性别影响了这些标志物与患者结果的关系.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
病理学病理学病理学

背景情况:

瘤坏死因子受体超级家族成员4 (TNFRSF4) 与癌症进展有关,特别是肝细胞癌 (HCC).
了解TNFRSF4在HCC的预后价值对于改善患者的治疗结果至关重要.

研究的目的:

为了研究TNFRSF4表达在HCC患者的预后意义.
开发和验证HCC中TNFRSF4表达的预测病理学模型.

主要方法:

从TCGA数据库中对HCCC患者队列进行RNA测序分析,以评估TNFRSF4表达和整体存活 (OS).
血素-氨酸染色和分析,以构建一个病理学模型来预测TNFRSF4表达.
路径丰富,免疫检查点标记物和免疫细胞透分析以阐明生物机制.

主要成果:

在HCC瘤组织中,TNFRSF4表达升高,与晚期病理阶段和残留瘤状况相关.
较高的TNFRSF4表达与不利的OS有关,特别是在男性HCC患者中.
病理学模型准确预测了TNFRSF4表达和相关的高分数与更糟糕的OS和男性死亡风险增加,涉及EMT和Tregs等途径.

结论:

TNFRSF4表达和病理学得分作为HCCOS的潜在预后生物标志物.
性别是影响TNFRSF4和HCC病理学得分的预后关联的一个重要因素.

关键词:

梯度增强模型的模型.肝细胞癌是肝细胞癌.最小的冗余性最大的相关性病理学是一种病理学.预测因素是一个预测因素.消除递归特征的消除.在TNFRSF4中.

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