免疫检查点抑制剂和毒性
F Bocchi1, S Häfliger2, S Schmid2
1Department for Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Heliyon
|June 6, 2024
概括
免疫检查点抑制剂 (ICI) 改善了癌症治疗,但可能导致脏损伤. 本综述详细介绍了ICI诱导的毒性,重点关注移植接受者和免疫抑制策略.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗,为各种恶性瘤提供了更好的生存率.
- ICI通过准免疫调节受体来增强抗瘤免疫反应而起作用.
- 尽管有效,但ICI与免疫相关的不良反应 (irAEs) 相关,包括毒性.
研究的目的:
- 审查ICI诱导的毒性病理生理学,临床表现和组织学特征.
- 专门针对接受ICI治疗的移植 (KT) 接受者的挑战和管理策略.
- 讨论免疫抑制中的治疗适应和在ICI上的KT患者中排斥的风险.
主要方法:
- 文献综述和现有关于ICI诱导毒性研究的综合.
- 分析与ICI脏不良事件相关的临床病例研究和组织学发现.
- 专注于移植患者的具体考虑,包括免疫抑制协议.
主要成果:
- 与ICI相关的毒性呈现出不同的临床和组织学模式.
- 治疗IRAE需要谨慎的诊断和治疗方法,通常涉及多学科的团队.
- 接受移植的接受者面临着独特的挑战,包括潜在的排斥和修改免疫抑制的需要.
结论:
- 了解ICI毒性对于优化癌症治疗和患者结果至关重要.
- 接受ICI的移植受体需要专门的管理协议,以平衡抗癌疗效与移植存活率.
- 需要进一步的研究来完善ICI诱导毒性的诊断和治疗策略,特别是在像KT接受者这样的脆弱人群中.
相关概念视频
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