维生素C适用于所有人吗?
Angelique de Man1, Micah T Long2, Christian Stoppe3,4
1Amsterdam UMC, location Vrije Universiteit, Department of Intensive Care, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherland.
Current opinion in critical care
|June 6, 2024
概括
高剂量的维生素C在严重疾病中显示出混合的结果. 虽然一些研究表明败血症和COVID-19的危害,但另一些研究表明心脏手术和烧伤患者的好处,需要进一步研究最佳剂量.
科学领域:
- 关键护理医学 关键护理医学
- 营养生物化学 营养生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 维生素C (甲酸) 在许多酶反应中充当电子捐赠体,这表明在危急疾病中具有潜在的治疗作用.
- 最近的随机对照试验 (RCT) 对重症患者的高剂量维生素C进行了研究,结果各不相同.
研究的目的:
- 审查最近关于维生素C作为重症患者辅助治疗的有效性和安全性的证据.
- 为了探索在特定条件的潜在益处,如败血症,COVID-19,和缺血症/再输液损伤.
主要方法:
- 分析了近期针对败血症,COVID-19,心脏手术和烧伤患者的大型随机对照试验 (RCT).
- 审查研究,检查维生素C对临床结果,生物标志物和生理参数的影响.
主要成果:
- 两项大型RCT表明,高剂量维生素C对败血症和COVID-19患者的潜在危害.
- 对心脏手术和烧伤患者的研究报告了改善的结果,包括心脏酶减少和流体需求减少.
- 维生素C可能有利于患有缺血/再损伤的患者,如心脏骤停后或器官移植后.
结论:
- 目前的证据是相互矛盾的,在一些人群中存在潜在的危害,而在另一些人群中则存在潜在的益处.
- 维生素C在危急疾病中的最佳时间,持续时间和个性化剂量策略需要进一步调查.
- 建议确保足够的基础维生素C水平,但确切的要求仍未确定.
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