复发性B组链球菌新生儿侵入性感染,法国,2007-2021年
Ghalia Sbaa1, Nicolas Delettre2, Cécile Guyonnet1,2,3
1Service de Bactériologie, Centre National de Référence des Streptocoques, Assistance Publique-Hôpitaux de Paris Centre, Paris, France.
The Journal of infectious diseases
|June 6, 2024
概括
在新生儿中,复发性B组链球菌 (GBS) 感染很少见,主要影响早产婴儿,并与高毒性CC17菌株有关. 为了找到最佳的管理策略,还需要进一步的研究.
科学领域:
- 新生儿传染病 新生儿传染病
- 细菌病原发生的细菌.
- 流行病学 流行病学
背景情况:
- 乙组链球菌 (GBS) 是新生儿感染的主要原因.
- 新生儿GBS感染的复发是一种罕见但严重的并发症.
- 了解GBS复发的风险因素对于预防和管理至关重要.
研究的目的:
- 调查复发性GBS新生儿侵入性感染的发病率和特征.
- 确定与新生儿GBS感染复发相关的风险因素.
- 探索可能导致GBS复发的微生物特征.
主要方法:
- 法国GBS新生儿侵入性感染的回顾性观察研究 (2007-2021年).
- 对1527例报告病例的分析,以确定复发性感染.
- 与婴儿特征 (早产,低出生体重) 和细菌因素 (克隆复合体,全基因组测序) 的关联分析.
主要成果:
- 1527例中的36例 (2.36%) GBS新生儿感染是复发性的.
- 复发病例主要涉及早产 (68%) 和低出生体重 (72%) 的婴儿.
- 复发与高病毒性GBS克隆复合体17 (83%; OR, 2.86) 有意义地相关.
- 没有检测到β-乳酸盐耐受性菌株,全基因组测序没有揭示特定的复发相关特征.
结论:
- 重复的GBS新生儿感染很少见,与早产,低出生体重和CC17 GBS菌株有关.
- 目前的微生物学分析无法解释复发的机制.
- 建议进行大型队列研究,以确定这些不常见的GBS感染的最佳管理.
相关概念视频
Factors Affecting the Risk of Infection
14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
5.7K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.7K
Healthcare Associated Infections II: Preventive Measures
4.7K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.7K
Development of the Oral Microbiota
65
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
65
Bacterial Meningitis I: Introduction
15
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
15
Bacterial Meningitis II: Pathophysiology
24
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
24


