剧烈强度体力活动对高风险高血压患者发生的认知障碍的影响
Richard Kazibwe1, Christopher L Schaich2, Ahmad Imtiaz Muhammad3
1Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
概括
充满活力的体力活动 (VPA) 可以防止高血压患者的认知能力下降. 每周至少进行一次VPA会话与轻度认知障碍和痴呆症的风险降低有关.
科学领域:
- 神经学 神经学
- 心血管健康 心血管健康
- 老年学是一门学科.
背景情况:
- 高血压显著增加了认知障碍和痴呆症的风险.
- 身体活动被认为具有减轻认知衰退的潜力.
- 了解强烈体力活动 (VPA) 在高风险人群中的具体影响至关重要.
研究的目的:
- 调查强烈体力活动 (VPA) 与发生轻度认知障碍 (MCI) 和可能痴呆的风险之间的关联.
- 评估定期VPA对高风险高血压患者认知功能的保护作用.
主要方法:
- 利用了SPRINT MIND试验的数据,重点关注患有高风险高血压的参与者.
- 将自我报告的VPA频率分为低 (<1次/周) 和高 (≥1次/周) 组.
- 采用多变量考克斯回归分析来评估VPA水平与认知结果之间的关系.
主要成果:
- 与VPA高的参与者相比,MCI,可能的痴呆症和MCI/可能的痴呆症相结合的发病率较低.
- 多变量分析显示,高VPA与降低MCI风险 (HR:0.81;95%CI:0.68-0.97) 和MCI/可能的痴呆症 (HR:0.82;95%CI:0.70-0.96) 显著相关.
- 观察到高VPA (HR:0.80;95%CI:0.63-1.03) 的可能痴呆症风险降低的趋势.
结论:
- 强烈的体力活动显示出在高血压患者中保持认知功能的潜力,这些人面临认知障碍的高风险.
- 在这个弱势群体中,定期参与VPA可以作为预防性策略来预防痴呆症和轻度认知障碍.
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